David Cranston MB ChB D Phil FRCS (Eng) FRCS (Ed)

Senior Lecturer in Surgery, Consultant Urological Surgeon

High Intensity Focused Ultrasound Unit

The High Intensity Focussed Ultrasound group was set in 2002 and has close international links with Chongqing in China. The group is currently investigating the treatment of solid tumours at the Churchill Hospital and has close research links with Professor Gail ter Haar, scientific director of the unit and Dr Constantin Coussios in Biomedical engineering.

Mr David Cranston

Email	david.cranston@orh.nhs.uk
Tel	01865 225381
Fax	01865 226086
PA	Carolyn Nelson
Email (PA)	carolyn.nelson@orh.nhs.uk
Tel (PA)	01865 225943
Fax (PA)	01865 226086
Contact address	Department of Urology, Churchill Hospital, Oxford, OX3 7LJ
College	Green Templeton College

Research

High Intensity Focused Ultrasound (HIFU) is a novel way of treating solid tumours using a non-invasive technique to cause local ablation. HIFU also has applications in other areas such as delivering drug therapy and vascular occlusion, as well as the potential for enhancing anti-tumour immunity. Oxford has established itself as one of the leading international academic centres for clinical HIFU research. The research programme initially centred on the HIFU unit at the Churchill Hospital, and is now expanding into a number of laboratory based projects around the University in both the translational and clinical setting.

Collaborators

Group Members

Gail ter Haar, Visiting Professor NDS
Constantin Coussios, Lecturer in Biomedical Engineering
Tom Leslie, Clinical lecturer NDS
Rob Ritchie, Research fellow

Biography

David Cranston trained in Bristol and worked in Exeter and Bath before coming to Oxford in 1983 to do research in renal transplantation under the direction of Professor Sir Peter Morris. He was awarded his D.Phil in 1986 and after a clinical lecturer post in urology and transplantation was appointed consultant urological and transplant surgeon in 1991. His special interest is in renal cancer and the urological complications of transplantation with a national referral for some patients needing complex renal cancer surgery.

In 1992 he set up an research programme with Professor Adrian Harris, Director of the cancer research unit in Oxford and has co supervised many research students who have carried out work in investigating bladder and kidney cancer. Several have won international awards for their work.

He has been clinical director of the High intensity focused ultrasound unit since 2002.

He is author of 18 book chapters and over 100 peer reviewed publications

Bibliography

Selected Bibliography

Leslie T A, Kennedy J E, Illing R O, Ter Haar G R, Wu F, Phillips R R, Friend P J, Roberts I SD, Cranston D W, and Middleton M R (2008) High-intensity focused ultrasound ablation of liver tumours: can radiological assessment predict the histological response? Br J Radiol, 81(967):564-71.

Illing R O, Kennedy J E, Wu F, ter Haar G R, Protheroe A S, Friend P J, Gleeson F V, Cranston D W, Phillips R R, and Middleton M R (2005) The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. Br J Cancer, 93(8):890-5.

Marberger Michael, Schatzl G, Cranston David, and Kennedy J E (2005) Extracorporeal ablation of renal tumours with high-intensity focused ultrasound. BJU Int, 95 Suppl 2:52-5.

Kennedy J E, Wu F, ter Haar G R, Gleeson F V, Phillips R R, Middleton M R, and Cranston D (2004) High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics, 42(1-9):931-5.

Kennedy J E, Ter Haar G R, and Cranston D (2003) High intensity focused ultrasound: surgery of the future? Br J Radiol, 76(909):590-9.