The Nuffield Department of Surgical Sciences
University of OxfordDerek W.R. Gray D. Phil (Oxon), FRCS, MRCP
| derek.gray@nds.ox.ac.uk | |
| Tel | 01865220145 |
| Fax | 01865768876 |
| Contact address | Nuffield Department of Surgical Sciences, Level 6, John Radcliffe Hospital, Headington, Oxford, OX3 9DU |
| College | Oriel College |
Research
Motivation:
The “complications” of diabetes condemn some patients to a shortened life of misery and are actually iatrogenic consequences of failure to regulate the blood glucose precisely by insulin therapy
Present Aims:
To contribute to the development of cellular transplantation as insulin replacement for type 1 diabetes that will be able to treat large numbers of patients, normalise the blood glucose metabolism, function long-term and not require toxic immunosuppression
Ultimate Aims
To contribute to prevention of type 1 diabetes by approaches based on knowledge of the mechanisms of immune tolerance.
Biography
I qualified in Medicine at Leeds Univesity, then based my surgical training and research in Oxford. My research interests have been in a variety of fields, including amputation surgery, non-specific abdominal pain, evaluation of teaching in Medical Schools , techniques of dialysis access surgery, and studies relating to kidney transplantation including biopsies to diagnose rejection, immunosuppression and prevention of thrombosis. However my major interest has focussed on various aspects of the development of islet transplantation as a treatment for type 1 diabetes and the role of MHC in the mechanisms of immunological tolerance.
Bibliography
Selected Bibliography
- Bates W D, Gray D WR, Dada M A, Chetty R, Gatter K C, Davies D R, and Morris P J (2003) Lymphoproliferative disorders in Oxford renal transplant recipients. J Clin Pathol, 56(6):439-46.
- Robertson A J, Nargund V, Gray D W, and Morris P J (2000) Low dose aspirin as prophylaxis against renal-vein thrombosis in renal-transplant recipients. Nephrol Dial Transplant, 15(11):1865-8.
- Gray D W and Ng R L (1990) Anatomical aspects of the blood supply to the skin of the posterior calf: technique of below-knee amputation. Br J Surg, 77(6):662-4.
- Sutton R, Gray D W, McShane P, Dallman M J, and Morris P J (1989) The specificity of rejection and the absence of susceptibility of pancreatic islet beta cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat. J Exp Med, 170(3):751-62.
- Gray D W and Morris P J (1987) The use of fluorescein diacetate and ethidium bromide as a viability stain for isolated islets of Langerhans. Stain Technol, 62(6):373-81.
- Pujol-Borrell R, Todd I, Doshi M, Bottazzo G F, Sutton R, Gray D, Adolf G R, and Feldmann M (1987) HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin. Nature, 326(6110):304-6.
- Pujol-Borrell R, Todd I, Doshi M, Gray D, Feldmann M, and Bottazzo G F (1986) Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol, 65(1):128-39.
- Gray D W, McShane P, Grant A, and Morris P J (1984) A method for isolation of islets of Langerhans from the human pancreas. Diabetes, 33(11):1055-61.
