Oxford Abdominal Aortic Aneurysm Study (OxAAA)
An aneurysm is present when an artery expands and becomes a "balloon" like structure. When left untreated, large aneurysms can burst suddenly and result in acute internal bleeding and subsequent mortality.
DID YOU KNOW: Albert Einstein died of a ruptured AAA!
Abdominal aortic aneurysm (AAA) is a common pathology which can result in rupture and high related mortality. It remains a important cause of death in developed countries. The pathophysiologic mechanisms governing AAA progression in humans is not fully understood. Currently, aneurysm size remains the best criteria for recommending surgery in large AAAs (>5.5cm). This has clear shortcomings, as aneurysm size is not an absolute predictor of aneurysm expansion and risk of rupture. There is a clear need to identify better substrates for risk stratification.
Systemic inflammation and associated abnormality of other vascular territories have been observed in AAA patients. Indeed it is increasingly recognised that vascular dysfunction is not limited to the AAA segment, but also present in the vessels elsewhere in the body. As the AAA progresses, it may lead to changes of proteins or metabolites found in blood circulation. These changes can now be studied in detail using a range of modern laboratory techniques.
The OxAAA study aims to improve our understanding of the underlying patho-physiology of aneurysm progression in humans by combining the information from comprehensive plasma molecular profiling and assessment of vascular tree by functional imaging. This will lead to identification of novel biomarkers of AAA progression and new risk stratification strategies for patients with AAAs.
Want to be part of OxAAA?
The success of OxAAA study relies on the active involvement of patient volunteers. Healthy volunteers are also important to us. Please contact the OxAAA team to find out more if you are interested to take part.
Interested to be part of the OxAAA research team? We have a range of research activities that are suited for people looking for either brief or long term research experience. Enquiries are welcome.
Division of Cardiovascular Medicine
- Prof Keith Channon
- Prof Charalambos Antoniades
Centre for Cardiovascular MRI
- Prof Stephan Neubauer
Clinical Cardiovascular Research Facility
- Prof Paul Leeson
NDM Target Discovery Institute
- Prof Benedikt Kessler
Institute of Biomedical Engineering
- Dr Eleanor Stride
Oxford Jackie Walton Vascular Studies Unit