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I obtained a first class honours degree and Ph.D. from the University of Sheffield, where I began my career in cancer-induced bone disease. Following postdoctoral studies at the University of Sheffield and the University of Oxford, i moved to the United States in 2004 to take up assistant professor positions at the University of Texas Health Science Center at San Antonio and subsequently at Vanderbilt University. I am the recipient of multiple awards and fellowships, including most recently, the Iain T. Boyle Award from the European Calcified Tissue Society. I relocated myr lab to the University of Oxford as a University Lecturer in Bone Oncology, with a joint appointment in NDS and the Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal Sciences, and a fellowship at St. Edmund Hall.
Cancer-induced bone disease is a characteristic feature of several types of cancer, including the haematological malignancy multiple myeloma, and other tumours that metastasise to bone such as breast, prostate and lung. In addition to the development of debilitating skeletal complications, the bone marrow provides a unique hospitable microenvironment, and once tumours become established in bone, they are largely unresponsive to treatment.
The overall goal of our research is to elucidate the cellular and molecular mechanisms that contribute to disease pathogenesis, and so identify and validate novel therapeutic approaches. Our focus is on the role of the tumour microenvironment and tumour-host interactions.
Major themes include; Obesity and adipokines in cancer-induced bone disease, MMPs in myeloma bone disease, miRNA in prostate cancer bone metastases and bone marrow stromal cells in the pathogenesis of cancer-induced bone disease