Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: The glial protein S100beta has been used to estimate cerebral damage in a number of clinical settings. The purpose of this investigation was to determine the correlation between cerebral microemboli and S100beta levels during cardiac operations. METHODS: Transcranial Doppler ultrasonography was used to measure emboli in the right middle cerebral artery. Emboli counts (n = 111) were divided into five time periods: (1) incision to aortic cannulation; (2) aortic cannulation to cross-clamp onset; (3) cross-clamp onset to cross-clamp release; (4) cross-clamp release to decannulation; and (5) decannulation to chest closure. The level of S100beta (n = 156) was measured at baseline, at the end of cardiopulmonary bypass, then 150 and 270 minutes after cross-clamp release. RESULTS: The level of S100beta correlated with age, cardiopulmonary bypass time, cross-clamp time, and number of emboli at time period 2. Although cardiopulmonary bypass time was univariately associated with S100beta level, it became nonsignificant in a multivariable model that included age and cross-clamp time. CONCLUSIONS: The correlation of S100beta level with emboli measured during cannulation (time period 2) supports the hypothesis that cannulation is a high-risk time period for cerebral injury.

Original publication

DOI

10.1016/s0003-4975(98)00276-8

Type

Journal article

Journal

Ann Thorac Surg

Publication Date

06/1998

Volume

65

Pages

1645 - 1649

Keywords

Age Factors, Analysis of Variance, Aorta, Biomarkers, Calcium-Binding Proteins, Cardiopulmonary Bypass, Cerebral Arteries, Constriction, Coronary Artery Bypass, Female, Follow-Up Studies, Humans, Intracranial Embolism and Thrombosis, Male, Middle Aged, Multivariate Analysis, Nerve Growth Factors, Risk Factors, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Time Factors, Ultrasonography, Doppler, Transcranial