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Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.

Original publication

DOI

10.1097/01.TP.0000106477.70852.29

Type

Journal article

Journal

Transplantation

Publication Date

15/01/2004

Volume

77

Pages

S6 - S8

Keywords

Cytokines, Humans, Isoantigens, Organ Transplantation, T-Lymphocytes, T-Lymphocytes, Regulatory, Transplantation Tolerance