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Transplantation is limited by the need for life-long pharmacological immunosuppression, which carries significant morbidity and mortality. Regulatory T cell (Treg) therapy holds significant promise as a strategy to facilitate immunosuppression minimization. Polyclonal Treg therapy has been assessed in a number of Phase I/II clinical trials in both solid organ and hematopoietic transplantation. Attention is now shifting towards the production of alloantigen-reactive Tregs (arTregs) through co-culture with donor antigen. These allospecific cells harbour potent suppressive function and yet their specificity implies a theoretical reduction in off-target effects. This review will cover the progress in the development of arTregs including their potential application for clinical use in transplantation, the knowledge gained so far from clinical trials of Tregs in transplant patients, and future directions for Treg therapy.

Original publication

DOI

10.1016/j.cellimm.2020.104214

Type

Journal article

Journal

Cell Immunol

Publication Date

11/2020

Volume

357

Keywords

Alloantigen-reactive Tregs, Cellular therapy, Clinical trials, Regulatory T cells, Transplantation, polyTregs, Animals, Graft Rejection, Humans, Immune Tolerance, Immunosuppression Therapy, Isoantigens, T-Lymphocytes, Regulatory, Transplantation Tolerance