Regulatory B cells in transplantation: roadmaps to clinic.

Beckett J., Hester J., Issa F., Shankar S.

Over the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transplant recipients demonstrate B-cell-associated gene signatures of immune tolerance, and novel therapeutic agents can induce Bregs in phase I clinical trials in transplantation. Our rapidly expanding appreciation of this novel B-cell subtype has made the road to clinical application a reality. Here, we outline several translational pathways by which Bregs could soon be introduced to the transplant clinic.

DOI

10.1111/tri.13706

Type

Journal article

Journal

Transpl Int

Publication Date

11/2020

Volume

33

Pages

1353 - 1368

Keywords

B cells, T cells, immunosuppression, immunosuppression experimental, macrophages, novel immunosuppressants, tolerance induction, tolerance strategies and mechanisms, Animals, B-Lymphocytes, Regulatory, Humans, Immune Tolerance, T-Lymphocytes, Regulatory, Transplantation Tolerance, Transplantation, Homologous

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