Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.

Original publication

DOI

10.1080/23723556.2018.1494950

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2018

Volume

5

Keywords

cancer stem cell, cell cycle, colorectal cancer, dormancy, hedgehog, heterogeneity, itraconazole, plasticity, wnt