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Outcomes after Localized Prostate Cancer TreatmentDonovan et al. present the long-term patient-reported outcomes of 1643 randomly assigned participants in the ProtecT (Prostate Testing for Cancer and Treatment) trial. Functional and quality-of-life impacts of prostatectomy, radiotherapy with neoadjuvant androgen deprivation, and active monitoring are described. Over the trial period from 7 to 12 years, generic quality-of-life scores were similar among all groups, with varying degrees of impact on urinary leakage, sexual function, and fecal leakage depending on the treatment group.

Original publication

DOI

10.1056/EVIDoa2300018

Type

Journal article

Journal

NEJM Evid

Publication Date

04/2023

Volume

2

Keywords

Male, Humans, Prostatic Neoplasms, Androgen Antagonists, Treatment Outcome, Quality of Life, Patient Reported Outcome Measures