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Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.

Type

Journal article

Journal

J Immunol

Publication Date

15/11/2002

Volume

169

Pages

5401 - 5404

Keywords

Adoptive Transfer, Animals, Antibodies, Monoclonal, Antigens, CD4, Antigens, CD40, CD4-Positive T-Lymphocytes, CD40 Ligand, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Graft Rejection, Heart Transplantation, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred NZB, Mice, Knockout, Mice, Transgenic, Receptors, Interleukin-2, Skin Transplantation, T-Lymphocyte Subsets