Dumbill R., Knight S., Hunter J., Fallon J., Voyce D., Barrett J., Ellen M., Conroy E., Roberts IS., James T., Allen G., Brook J., Weissenbacher A., Ploeg R., Coussios C., Friend P.

Kidney transplantation is the preferred treatment for end-stage renal disease and is limited by donor organ availability. Normothermic Machine Perfusion (NMP) might facilitate safe transplantation of marginal organs. NKP1 is a single centre, phase 1, 36-patient, three-stage cohort study investigating the safety and feasibility of up to 24 hours of renal NMP prior to transplantation. 30-day graft survival (primary endpoint) was 100%. Secondary objectives were assessment of the effect of NMP on post-transplant clinical outcomes and ischaemia-reperfusion injury, identification of predictive biomarkers, and characterisation of the performance of the preservation system. Clinical outcomes were comparable to a matched control cohort with 12-month estimated glomerular filtration rate (eGFR) 46.3 vs 49.5 mL/min/1.73m2 (p = 0.44) despite much longer total preservation times (15.7 vs 8.9 hours controls, p

Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study.

Dumbill R., Knight S., Hunter J., Fallon J., Voyce D., Barrett J., Ellen M., Conroy E., Roberts IS., James T., Allen G., Brook J., Weissenbacher A., Ploeg R., Coussios C., Friend P.

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