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Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P = 0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.

Original publication

DOI

10.1111/tri.12563

Type

Journal article

Journal

Transpl Int

Publication Date

09/2015

Volume

28

Pages

1028 - 1033

Keywords

graft survival, pancreas transplant, predictor, risk, Adult, Cohort Studies, Databases, Factual, Female, Graft Survival, Humans, Kaplan-Meier Estimate, Kidney Transplantation, Male, Middle Aged, Pancreas, Pancreas Transplantation, Proportional Hazards Models, Registries, Risk Factors, Severity of Illness Index, Tissue Donors, Tissue and Organ Procurement, Treatment Outcome, United Kingdom