High-intensity focused ultrasonic ablation of sacral chordoma is feasible: a series of four cases and details of a national clinical trial.

Gillies MJ., Lyon PC., Wu F., Leslie T., Chung DY., Gleeson F., Cranston D., Bojanic S.

High-intensity focused ultrasound describes the use of high-intensity focused ultrasound (HIFU) to ablate tumours without requiring an incision or other invasive procedure. This technique has been trialled on a range of tumours including uterine fibroids, prostate, liver and renal cancer. We describe our experience of using HIFU to ablate sacral chordoma in four patients with advanced tumours. Patients were treated under general anaesthetic or sedation using an ultrasound-guided HIFU device. HIFU therapy was associated with a reduction in tumour volume over time in three patients for whom follow up scans were available. Tumour necrosis was reliably demonstrated in two of the three patients. We have established a national trial to assess if HIFU may improve long-term outcome from sacral chordoma, details are given.

DOI

10.1080/02688697.2016.1267330

Type

Journal article

Journal

Br J Neurosurg

Publication Date

08/2017

Volume

31

Pages

446 - 451

Keywords

Sacral chordoma, ablative therapy, high-intensity focused ultrasound, national clinical trial, Adolescent, Anesthesia, General, Child, Child, Preschool, Chordoma, Feasibility Studies, Female, High-Intensity Focused Ultrasound Ablation, Humans, Infant, Male, Necrosis, Patient Care Team, Postoperative Complications, Sacrococcygeal Region, Spinal Neoplasms, Treatment Outcome

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