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INTRODUCTION: It is common practice to irrigate the operative site following tumor resection during major head and neck surgery. A variety of irrigation solutions are used, but there are few data on their relative efficacies in this context. METHODS: The effect of different irrigation solutions on cell survival was assessed by clonogenic survival assay in 5 head and neck squamous cell carcinoma cell lines at different time points. RESULTS: Saline had no effect on cell survival in any of the cell lines tested. Hydrogen peroxide, povidone-iodine, and a hydrogen peroxide/povidone-iodine mix caused complete cell death in all cell lines. Irrigation with distilled water caused a significant reduction in cell survival in 3 cell lines. Duration of exposure showed no effect on cell survival. CONCLUSION: These data suggest a significant difference in the cytocidal effect of commonly used irrigation solutions on head and neck cancer cells in an in vitro model.

Original publication

DOI

10.1177/0003489414543101

Type

Journal article

Journal

Ann Otol Rhinol Laryngol

Publication Date

01/2015

Volume

124

Pages

68 - 71

Keywords

head and neck cancer treatment, squamous cell carcinoma, wound irrigation, Anti-Infective Agents, Local, Carcinoma, Squamous Cell, Cell Culture Techniques, Cell Line, Tumor, Cell Survival, Head and Neck Neoplasms, Humans, Hydrogen Peroxide, Pharmaceutical Solutions, Povidone-Iodine, Sodium Chloride, Squamous Cell Carcinoma of Head and Neck, Therapeutic Irrigation, Water