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LOCATION:

John Radcliffe Hospital, West Wing, Level 6, Headley Way, Headington, Oxford, OX3 9DU

DPhil start date

October 2018

Project title

The Interpretation of Deep Brain Stimulation through Diffusion-Weighted Magnetic Resonance Imaging

Supervisor

Professor Alex Green

Professor Stephen Payne

Professor Tipu Aziz

Ashley Raghu

BSc (Hons)


DPhil student

  • Junior Dean, Pembroke College

I read Chemical Sciences at the University of St Andrews where I focused on physical and inorganic chemistry and took a minor in neurosciences. From there I stayed in Scotland to study Medicine at the University of Edinburgh, where I developed a passion for neurosurgery. I am currently in my final year reading for a DPhil in Surgical Sciences within the Oxford Functional Neurosurgery group, headed by Professor Tipu Aziz. I graduate both medical school and my doctoral programme this year. 

My doctoral research is supervised by consultant neurosurgeon-neuroscientist Professor Alex Green, Professor Stephen Payne, head of the Cerebral Haemodynamics group, and Professor Aziz. I am leveraging neuroimaging-based estimates of structural connectivity to gain insights into deep brain stimulation. Specifically, I am studying a) surgery to the pedunculopontine nucleus in the treatment of Parkinson’s disease, b) surgery to the somatosensory thalamus and anterior cingulate in the treatment of chronic neuropathic pain, c) surgery to the internal pallidum in the treatment of cervical dystonia, and d) surgery to the motor thalamus in the treatment of a range of tremor disorders.

Publications

Multitarget deep brain stimulation for clinically complex movement disorders.

Parker T, Raghu ALB, FitzGerald JJ, Green AL, Aziz TZ. J Neurosurg. 2020 Jan 3:1-6.

Tractography patterns of pedunculopontine nucleus deep brain stimulation.

Raghu ALB, Parker T, Zand APD, Payne S, Andersson J, Stein J, Aziz TZ, Green AL. J Neural Transm (Vienna). 2021 May;128(5):659-670.

Connectivity-based thalamus parcellation and surgical targeting of somatosensory subnuclei.

Raghu ALB, Martin SC, Parker T, Aziz TZ, Green AL. J Neurosurg. 2021 Nov 19:1-8.

Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia.

Raghu ALB, Eraifej J, Sarangmat N, Stein J, FitzGerald JJ, Payne S, Aziz TZ, Green AL. Brain. 2021 Dec 31;144(12):3589-3596.