- 2017 Calne Williams Medal, The British Transplantation Society
MRC Clinical Research Training Fellow and DPhil candidate
My research focuses on optimising steatotic (fatty) livers for transplantation through the use of normothermic machine perfusion (NMP) technology and de-fatting strategies.
Liver transplantation has become a victim of its own success and 20% of patients on the UK waiting list die without a liver transplant. Steatotic (fatty) livers derive particularly poor outcomes when transplanted and a result a large number are discarded. With the global obesity epidemic, an increasing number of steatotic livers in the donor pool is inevitable and identifying methods to salvage these livers is of great importance.
Normothermic machine perfusion (NMP) is a novel preservation technique which maintains the liver in a fully functioning state ex vivo; providing it with oxygen and nutrition at normal body temperature. This facilitates extended preservation times, functional liver assessment and the potential for liver-directed therapeutic interventions.
I am undertaking clinical perfusion studies of steatotic human livers which have been deemed too high risk for transplantation. By perfusing the livers for 48 hours with de-fatting agents and other adjuncts, I hope to gain an understanding of NMP’s potential in the enhanced preservation and de-fatting of steatotic livers. Through the use of stable isotope tracers, I plan to gain an understanding of the metabolic pathways involved in the de-fatting process.
Delayed graft function is a syndrome rather than a diagnosis.
Aitken E. et al, (2015), Exp Clin Transplant, 13, 19 - 25
Contemporary outcomes of open repair of thoracoabdominal aortic aneurysm in young patients.
Johns N. et al, (2014), J Cardiothorac Surg, 9
Outcomes of renal transplantation in patients with major lower limb amputation.
Ceresa CD. et al, (2014), Transplant Proc, 46, 115 - 120
Mesenchymal stromal cells promote bowel regeneration after intestinal transplantation: Myth to mucosa
Ceresa CDL. et al, (2013), Transplant International, 26
A single center experience of abdominal wall graft rejection after combined intestinal and abdominal wall transplantation
Allin BSR. et al, (2013), American Journal of Transplantation, 13, 2211 - 2215