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John Radcliffe Hospital, Level 5 and 6, Headley Way, Headington, Oxford, OX3 9DU

DPhil start date

7 October 2019

Project title

Hypoxia in Tregs


Dr Joanna Hester and Dr Fadi Issa

Marie Sion

BSc (Hons)

DPhil student

I completed my undergraduate studies in Biomedical Science at University College London (UCL), focussing my dissertation on interactions between NK cells and Tregs in cancer in Mark Lowdell’s lab.

I am a student in the TRIG group headed by Joanna Hester and Fadi Issa, and my project is based on a collaboration with Chris Pugh. We are investigating the role of hypoxia in regulatory T cells (Tregs), in order to manipulate Treg function. Tregs are very important for maintaining tolerance and reducing transplant rejection, so any method to regulate their function has tremendous therapeutic advantage.