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Masateru Uchiyama

M.D., Ph.D.

Postdoctoral Researcher in Transplantation Immunology

My research focuses on the induction of regulatory T cells (Tregs) and regulation of chronic rejection.

Currently, many major drugs for immunosuppression such as steroids could help to improve transplant patients’ survival concerning acute rejection. However, chronic rejection still poses many obstacles. Ultimately, I believe that the improvement of transplantation outcomes in the future is dependent on whether we can harness regulatory T cells to control chronic rejection.

I aim to investigate reliable mechanisms to induce the expansion of stable Tregs and chronic rejection to further this goal. Thus, I believe that it is first necessary in this line of research to elucidate the fundamental pathways and differentiation of Tregs in long-term survival grafts.

The elucidation will help to improve transplant survival data in acute and chronic phase of rejection and reduce the dependence to harmful immunosuppressive agents within the term.

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