MSci (Hons), PhD
My research focuses on the breakdown of the extracellular matrix during islet isolation. I investigate how specific enzymes digest the islet-exocrine interface in order to release islets, particularly with respect to donor characteristics such as age and BMI. By tailoring the enzymes to the donor organ, this may result in improved pancreatic islet cell yield. Subsequently, this would allow a greater transplantation rate and treatment of patients with type 1 diabetes.
I am also an active member of the clinical islet isolation team so my research directly translates into medical application.
Donor age significantly influences the Raman spectroscopic biomolecular fingerprint of human pancreatic extracellular matrix proteins following collagenase-based digestion.
Spiers RM. et al, (2019), Acta Biomater, 99, 269 - 283
Does Islet Size Really Influence Graft Function After Clinical Islet Transplantation?
Hughes SJ. et al, (2018), Transplantation, 102, 1857 - 1863
Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation.
Cross SE. et al, (2017), Am J Transplant, 17, 451 - 461
Both layers of the human islet double basement membrane are substantially disrupted during islet isolation
Cross S. et al, (2015), XENOTRANSPLANTATION, 22, S189 - S190
BOTH LAYERS OF THE HUMAN ISLET DOUBLE BASEMENT MEMBRANE ARE SUBSTANTIALLY DISRUPTED DURING ISLET ISOLATION.
Cross S. et al, (2015), TRANSPLANTATION, 99, S316 - S316