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Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p 

Original publication

DOI

10.1038/s41467-021-21287-0

Type

Journal article

Journal

Nat Commun

Publication Date

23/02/2021

Volume

12

Keywords

Aged, Ethnic Groups, Humans, Male, Middle Aged, Multifactorial Inheritance, Multivariate Analysis, Neoplasm Invasiveness, Prostatic Neoplasms, Self Report