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Protective monoclonal antibodies (MAbs) to the major outer membrane protein (MOMP) of species of the family Chlamydiaceae, which is the primary vaccine candidate antigen, recognize nonlinear epitopes conferred by the oligomeric conformation of the molecule. Protective MAbs failed to recognize oligomeric MOMP of the variant strain LLG, which bears amino acid substitutions in variable segments (VSs) 1, 2, and 4, and competed with monomer-specific MAbs mapping to these VSs in reference strain 577. The results suggest that multiple sites located in the three VSs contribute to the epitope of protective MAbs.

Original publication




Journal article


Infect Immun

Publication Date





607 - 612


Amino Acid Sequence, Antibodies, Monoclonal, Bacterial Outer Membrane Proteins, Chlamydophila psittaci, Epitope Mapping, Molecular Sequence Data, Porins