Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
Huynh-Le M., Karunamuni R., Fan CC., Asona L., Thompson WK., Martinez ME., Eeles RA., Kote-Jarai Z., Muir KR., Lophatananon A., Schleutker J., Pashayan N., Batra J., Grönberg H., Neal DE., Nordestgaard BG., Tangen CM., MacInnis RJ., Wolk A., Albanes D., Haiman CA., Travis RC., Blot WJ., Stanford JL., Mucci LA., West CML., Nielsen SF., Kibel AS., Cussenot O., Berndt SI., Koutros S., Sørensen KD., Cybulski C., Grindedal EM., Menegaux F., Park JY., Ingles SA., Maier C., Hamilton RJ., Rosenstein BS., Lu Y., Watya S., Vega A., Kogevinas M., Wiklund F., Penney KL., Huff CD., Teixeira MR., Multigner L., Leach RJ., Brenner H., John EM., Kaneva R., Logothetis CJ., Neuhausen SL., De Ruyck K., Ost P., Razack A., Newcomb LF., Fowke JH., Gamulin M., Abraham A., Claessens F., Castelao JE., Townsend PA., Crawford DC., Petrovics G., van Schaik RHN., Parent M., Hu JJ., Zheng W., Mills IG., Andreassen OA., Dale AM., Seibert TM., UKGPCS collaborators None., APCB (Australian Prostate Cancer BioResource) None., NC-LA PCaP Investigators None., The IMPACT Study Steering Committee and Collaborators None., Canary PASS Investigators None., The Profile Study Steering Committee None., The PRACTICAL Consortium None.
Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets.