A GMP Protocol for the Manufacture of Tregs for Clinical Application.

O'Neil A., Brook M., Abdul-Wahab S., Hester J., Lombardi G., Issa F.

Infusion of regulatory T cells is a promising therapeutic strategy in organ transplantation to modulate the immune system, prevent rejection, minimize the need for pharmaceutical immunosuppression, and improve long-term transplant outcomes. Here we describe a GMP-compliant method we have used for the manufacture of ex vivo expanded autologous regulatory T cells for use in clinical trials.

DOI

10.1007/978-1-0716-2647-4_14

Type

Chapter

Publication Date

2023

Volume

2559

Pages

205 - 227

Keywords

Immunosuppression minimization, Regulatory T cells, Tolerance, Transplantation, Treg, Graft Rejection, Immune Tolerance, Immunosuppression Therapy, Organ Transplantation, Pharmaceutical Preparations, T-Lymphocytes, Regulatory

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