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There has recently been an explosion of renewed interest in regulatory T cells, particularly those within the CD4(+)CD25(+) population. It is becoming increasingly apparent that these cells exist not only as naturally occurring cells that may contribute to the maintenance of self-tolerance, but they also have the potential to prevent rejection of allografts in experimental models. Such cells have now been identified in humans as well as in rodents.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/2002

Volume

14

Pages

584 - 591

Keywords

Animals, Cytokines, Humans, Immunophenotyping, Interleukin-2, Isoantigens, Leukocyte Common Antigens, Receptors, Interleukin-2, T-Lymphocytes, Transplantation Immunology