Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the origin, allorecognition properties and molecular basis for the suppressive activity of CD4+CD25+ T(Reg) cells, as well as their relationship to other populations of regulatory cells that exist after transplantation, remain a matter of debate..

Original publication

DOI

10.1038/nri1027

Type

Journal article

Journal

Nat Rev Immunol

Publication Date

03/2003

Volume

3

Pages

199 - 210

Keywords

Animals, CD4 Antigens, Graft Rejection, Humans, Isoantigens, Lymphocyte Subsets, Receptors, Interleukin-2, Species Specificity, T-Lymphocytes, Regulatory, Transplantation Immunology, Transplantation Tolerance