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Regulatory T cells (Treg) suppress immune responses, making them an exciting therapeutic target for achieving operational transplant tolerance. Recent observations have identified forkhead box P3 (FOXP3) as a master gene required for the development and function of Treg. Improving our understanding of FOXP3 may facilitate methods for identifying and generating Treg.

Original publication

DOI

10.1097/01.tp.0000275424.52998.ad

Type

Journal article

Journal

Transplantation

Publication Date

27/08/2007

Volume

84

Pages

459 - 461

Keywords

Forkhead Transcription Factors, Humans, Organ Transplantation, T-Lymphocytes, Regulatory, Transplantation Tolerance