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Interleukin-23 (IL-23) and the recently discovered Th17 cells have been implicated in the pathogenesis of autoimmune diseases. This review will discuss current understanding of T-cell subsets in transplantation immunity and will explore the role of IL-23 and Th17 cells in allograft rejection, tolerance, and ischemia reperfusion injury.

Original publication

DOI

10.1097/01.tp.0000287126.12083.48

Type

Journal article

Journal

Transplantation

Publication Date

15/11/2007

Volume

84

Pages

1071 - 1074

Keywords

CD4-Positive T-Lymphocytes, Graft Rejection, Humans, Interferon-gamma, Interleukin-17, Interleukin-23, Th1 Cells, Th2 Cells, Transplantation Immunology