Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

T regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance. Recent findings in experimental transplant models combined with the development of functional reporter mice have opened new avenues to study Treg biology and their therapeutic potential. In particular, recent advances in understanding Treg function and lineage stability revealed unexpected plasticity of this lineage. Nevertheless, pre-clinical and pilot clinical trials using Treg cells as cellular therapies have been initiated suggesting the safety and feasibility of such treatment.

Original publication

DOI

10.1016/j.coi.2010.08.011

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/2010

Volume

22

Pages

662 - 668

Keywords

Animals, Cell Differentiation, Cell Lineage, Clinical Trials as Topic, Forkhead Transcription Factors, Humans, Immune Tolerance, Mice, T-Lymphocytes, Regulatory, Transplantation, Homologous