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T Regulatory cells (Treg) play an important role in the induction and maintenance of immunological tolerance to self and alloantigens. Recent findings in experimental transplant models have demonstrated that Treg can control acute and delayed allograft rejection. Preclinical attempts to use Treg as a cellular therapy have been successfully undertaken demonstrating the safety and feasibility of such treatment, suggesting that they have therapeutic potential.

Original publication

DOI

10.1016/j.transproceed.2011.06.050

Type

Journal article

Journal

Transplant Proc

Publication Date

07/2011

Volume

43

Pages

2135 - 2136

Keywords

Animals, Graft Rejection, Graft Survival, Humans, Immune Tolerance, Isoantigens, Organ Transplantation, T-Lymphocytes, Regulatory, Transplantation Immunology