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The purpose of this review is to examine recent evidence that investigates the role of the insulin-like growth factor (IGF) system in colorectal cancer. We concentrate on the evidence that makes the case for the investigation of strategies that might be used to disrupt the IGF system in prevention and treatment. Even though the weight of evidence suggests that components of the IGF system may be appropriate targets, there are a lack of studies that make a systematic characterisation of all the system components in human colorectal cancer. It is anticipated that this information, and the new therapeutic molecules which follow, will impact on the prevention and treatment of patients with this disease.

Original publication

DOI

10.1093/annonc/mdf096

Type

Journal article

Journal

Ann Oncol

Publication Date

03/2002

Volume

13

Pages

349 - 356

Keywords

Animals, Colorectal Neoplasms, Humans, Mice, Somatomedins