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As islet transplantation increasingly enters the clinical arena, its coexistence with vascularized pancreas transplantation makes it necessary to reassess the questions of donor selection and allocation. In answering these questions, one must put in the balance the short-term morbidity of pancreas transplantation with the long-term attrition of islet grafts. The preferential allocation of pancreases from obese and older donors for islet isolation has been based on their association with worse pancreas transplant outcomes and better islet isolation results in islet yields. In this overview, we show that transplanted islet mass does not necessarily correlate with graft function and make the case that donor selection criteria for islet transplantation, and hence allocation rules, may need to be redefined.

Original publication

DOI

10.1097/TP.0b013e3181e25a40

Type

Journal article

Journal

Transplantation

Publication Date

15/08/2010

Volume

90

Pages

238 - 243

Keywords

Age Factors, Body Mass Index, Donor Selection, Graft Survival, Health Care Rationing, Humans, Islets of Langerhans Transplantation, Pancreas Transplantation, Practice Guidelines as Topic, Quality of Health Care, Risk Assessment, Risk Factors, Time Factors, Tissue Donors, Tissue and Organ Procurement, Treatment Outcome