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Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centers on the facilitation of donor-cell mixed chimerism in the transplant recipient with the use of bone marrow or hematopoietic stem cell transplantation. The second strategy, utilizing peripheral regulatory mechanisms, focuses on cellular therapy with regulatory T cells. This review examines the key studies and novel research directions in the field of immunological tolerance.

Original publication

DOI

10.3389/fimmu.2012.00254

Type

Journal article

Journal

Front Immunol

Publication Date

2012

Volume

3

Keywords

cellular therapy, chimerism, clinical trials, immune regulation, regulatory T cell, tolerance, transplantation