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BACKGROUND: A common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated. METHODS: We investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-control study of 1503 case subjects and 1503 control subjects among black, Latino, Japanese, Native Hawaiian, and white men from the Multiethnic Cohort study. We also examined the ability of MSP to serve as a biomarker for discriminating prostate cancer case subjects from control subjects. All statistical tests are two-sided. RESULTS: In all racial and ethnic groups, men with lower MSP levels were at greater risk of developing prostate cancer (odds ratio = 1.02 per one unit decrease in MSP, P < .001 in the prostate-specific antigen [PSA]-adjusted analysis). Compared with men in the highest decile of MSP, the multivariable PSA-adjusted odds ratio was 3.64 (95% confidence interval = 2.41 to 5.49) for men in the lowest decile. The positive association with lower MSP levels was observed consistently across racial and ethnic populations, by disease stage and Gleason score, for men with both high and low levels of PSA and across all genotype classes of rs10993994. However, we did not detect strong evidence of MSP levels in improving prostate cancer prediction beyond that of PSA. CONCLUSIONS: Regardless of race and ethnicity or rs10993994 genotype, men with low blood levels of MSP have increased risk of prostate cancer.

Original publication

DOI

10.1093/jnci/djs486

Type

Journal article

Journal

J Natl Cancer Inst

Publication Date

06/02/2013

Volume

105

Pages

237 - 243

Keywords

Aged, Asian Continental Ancestry Group, Biomarkers, Tumor, California, Case-Control Studies, Cohort Studies, European Continental Ancestry Group, Genotype, Hawaii, Hispanic Americans, Humans, Male, Middle Aged, Oceanic Ancestry Group, Odds Ratio, Predictive Value of Tests, Prostatic Neoplasms, Prostatic Secretory Proteins, Risk Assessment, Risk Factors, Surveys and Questionnaires