Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Kallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2, hk2, and prostate-specific antigen (PSA). Members of the so-called classic kallikreins, these highly active trypsin-like serine proteases play established roles in human reproduction. Both hK2 and PSA expression is regulated by the androgen receptor which has a fundamental role in prostate tissue development and progression of disease. This feature, combined with the ability to sensitively detect different forms of these proteins in blood and biopsies, result in a crucially important biomarker for the presence and recurrence of cancer. Emerging evidence has begun to suggest a role for these kallikreins in critical vascular events. This review discusses the established and developing biological roles of hK2 and PSA, as well as the historical and advanced use of their detection to accurately and non-invasively detect and guide treatment of prostatic disease.

Original publication

DOI

10.1160/TH13-04-0275

Type

Journal article

Journal

Thromb Haemost

Publication Date

09/2013

Volume

110

Pages

484 - 492

Keywords

Biomarkers, Tumor, Disease Progression, Enzyme-Linked Immunosorbent Assay, Equipment Design, Gene Expression Regulation, Neoplastic, Humans, Male, Models, Molecular, Neovascularization, Pathologic, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Protein Conformation, Receptors, Androgen, Tissue Kallikreins, Trypsin