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© 2013 Springer Science+Business Media New York. All rights reserved. Brain death (BD) influences the early course of allografts by triggering a series of nonspecific inflammatory events. A distinct role for innate immunity in the initiation phase of tissue damage following BD and the inflammatory response is increasingly appreciated. In this chapter, the role of innate immunity in BD-induced inflammation will be addressed, focused on two major systems of innate immunity-toll-like receptors (TLRs) and complement.

Original publication





Book title

The Brain-Dead Organ Donor: Pathophysiology and Management

Publication Date





139 - 145