Age-specific incidence, risk factors and outcome of acute abdominal aortic aneurysms in a defined population
Howard DPJ., Banerjee A., Fairhead JF., Handa A., Silver LE., Rothwell PM.
© 2015 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd. Background Contemporary population-based data on age-specific incidence and outcome from acute abdominal aortic aneurysm (AAA) events are needed to understand the impact of risk factor modification and demographic change, and to inform AAA screening policy. Methods In a prospective population-based study (Oxfordshire, UK, 2002-2014), event rates, incidence, early case fatality and long-term outcome from all acute AAA events were determined, both overall and in relation to the four main risk factors: smoking, hypertension, male sex and age. Results Over the 12-year interval, 103 incident acute AAA events occurred in the study population of 92728 (men 72·8 per cent; 59·2 per cent 30-day case fatality rate). The incidence per 100000 population per year was 55 in men aged 65-74years, but increased to 112 at age 75-84years and to 298 at age 85years or above. Some 66·0 per cent of all events occurred in those aged 75years or more. The incidence at 65-74years was highest in male smokers (274 per 100000 population per year); 27 (96 per cent) of 28 events in men aged less than 75years occurred in ever-smokers. Mean(s.d.) age at event was lowest in current smokers (72·2(7·2) years), compared with that in ex-smokers (81·2(7·0) years) and never-smokers (83·3(7·9) years) (P < 0·001). Hypertension was the predominant risk factor in women (diagnosed in 93 per cent), with 20 (71 per cent) of all 28 events in women occurring in those aged 75years or above with hypertension. The 30-day case fatality rate increased from 40 per cent at age below 75years to 69 per cent at age 75years or more (P=0·008). Conclusion Two-thirds of acute AAA events occurred at age 75years or above, and more than 25 per cent of events were in women. Taken with the strong associations with smoking and hypertension, these findings could have implications for AAA screening. Comprehensive cohort study