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Expression of the epidermal growth factor (EGF) receptor was evaluated by immunohistochemical staining of formalin-fixed, paraffin-embedded tumour tissues employing two antibodies raised to short synthetic peptides from the cytoplasmic domain of the molecule. Both antibodies gave concordant staining of a series of bladder cancers known to express or lack EGF receptors. There was no cross-reaction with the related c-erbB-2 protein, which was also over-expressed in some cases. Cancers with EGF receptor expression also expressed high levels of TGF-alpha, a receptor agonist.

Original publication

DOI

10.1002/path.1711640403

Type

Journal article

Journal

J Pathol

Publication Date

08/1991

Volume

164

Pages

285 - 289

Keywords

Antibodies, Monoclonal, Gene Expression, Humans, Immunohistochemistry, Paraffin, Proto-Oncogene Proteins, Proto-Oncogenes, Receptor, Epidermal Growth Factor, Receptor, ErbB-2, Transforming Growth Factor alpha, Urinary Bladder Neoplasms