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Overlooked for decades, the humoral alloimmune response is increasingly recognized as a leading cause of graft loss after transplantation. However, improvement in the diagnosis of antibody-mediated rejection has not yet translated into better outcomes for transplanted patients. After an update on B cell physiology and antibody generation, the 2015 Beaune Seminar in Transplant Research challenged the conventional view of antibody-mediated rejection pathophysiology and discussed the latest promising therapeutic approaches.

Original publication

DOI

10.1097/TP.0000000000001069

Type

Journal article

Journal

Transplantation

Publication Date

07/2016

Volume

100

Pages

1460 - 1464

Keywords

Antibodies, B-Lymphocytes, Congresses as Topic, France, Graft Rejection, Graft Survival, Humans, Immune Tolerance, Immunity, Humoral, Immunoglobulin G, Immunosuppression, Immunosuppressive Agents, Transplantation, Transplantation, Homologous