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Multiple myeloma is a tumour with a remarkably destructive effect on its host organ, the bone marrow. Through expression or secretion of adhesion molecules, growth factors, exosomes, miRNAs, chemokines and inhibitors, the tumour substantially alters its microenvironment, promoting both tumour survival and osteolytic bone disease. This altered niche is ideally suited to the sustenance of its proliferating compartment and the protection and immune evasion of its dormant, drug resistant fraction. The possibility of deepening response to a drug treatment regime, maintaining remission or even eradicating resistant stem cells by pharmacologically manipulating the tumour's interactions with this niche is a major driving force in current myeloma research. Examples of promising therapies include CXCR4 antagonists, RANKL inhibitors, HIF1α pathway inhibitors, and inhibitors of Notch, Wnt and TGFβ family pathways.

Original publication

DOI

10.1016/j.coph.2016.02.013

Type

Journal article

Journal

Curr Opin Pharmacol

Publication Date

06/2016

Volume

28

Pages

43 - 49

Keywords

Animals, Antineoplastic Agents, Bone Marrow, Drug Design, Drug Resistance, Neoplasm, Humans, Multiple Myeloma, Neoplastic Stem Cells, Osteolysis, Tumor Microenvironment