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To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.

Original publication

DOI

10.1080/23723556.2016.1140262

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

05/2016

Volume

3

Keywords

Androgen Receptor, chaperones, prostate cancer, therapeutic target