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A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.

Original publication

DOI

10.1111/j.1600-0854.2009.00922.x

Type

Journal article

Journal

Traffic

Publication Date

09/2009

Volume

10

Pages

1209 - 1220

Keywords

Active Transport, Cell Nucleus, Adaptor Proteins, Vesicular Transport, Animals, Cell Nucleus, Cytoplasm, Endocytosis, Endosomes, Humans, Neoplasms