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A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

Original publication

DOI

10.1038/ng.2881

Type

Journal article

Journal

Nat genet

Publication Date

02/2014

Volume

46

Pages

94 - 95

Keywords

Chromatin, Chromosomes, Human, Pair 6, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Homeodomain Proteins, Humans, Male, Prostatic Neoplasms, Regulatory Factor X Transcription Factors, Transcription Factors