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The presence of an unusual HLA class I reactivity pattern was detected in a Caucasoid-Asian individual by PCR-sequence specific primer (PCR-SSP) typing. Exons 2 and 3 were characterized using PCR-sequence-based typing (PCR-SBT) and were found to contain a novel Cw*03 sequence, Cw*0315. In the region studied, Cw*0315 was comprised mainly of the Cw*0302 sequence, but at four positions it contained nucleotides normally only found in other HLA Cw locus alleles. These positions each resulted in an amino acid substitution.

Type

Journal article

Journal

Tissue Antigens

Publication Date

11/2002

Volume

60

Pages

404 - 406

Keywords

Base Sequence, HLA-C Antigens, Humans, Molecular Sequence Data, Mutation, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Sequence Alignment