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Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense. Over recent years these cells have been characterized in detail with the use of cell surface markers and flow cytometry, and subpopulations have been described. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. This classification has been approved by the Nomenclature Committee of the International Union of Immunological Societies, and we are convinced that it will facilitate communication among experts and in the wider scientific community.

Original publication

DOI

10.1182/blood-2010-02-258558

Type

Journal article

Journal

Blood

Publication Date

21/10/2010

Volume

116

Pages

e74 - e80

Keywords

Animals, Blood Cells, Dendritic Cells, Humans, Mice, Monocytes, Terminology as Topic