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Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p 

Original publication

DOI

10.1038/s41467-018-06863-1

Type

Journal article

Journal

Nat Commun

Publication Date

05/11/2018

Volume

9

Keywords

Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 8, Disease Susceptibility, European Continental Ancestry Group, Genetic Markers, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Prostatic Neoplasms, Risk Assessment, Risk Factors