Long-term prediction of prostate cancer: prostate-specific antigen (PSA) velocity is predictive but does not improve the predictive accuracy of a single PSA measurement 15 years or more before cancer diagnosis in a large, representative, unscreened population.
Ulmert D., Serio AM., O'Brien MF., Becker C., Eastham JA., Scardino PT., Björk T., Berglund G., Vickers AJ., Lilja H.
PURPOSE: We tested whether total prostate-specific antigen velocity (tPSAv) improves accuracy of a model using PSA level to predict long-term risk of prostate cancer diagnosis. METHODS: During 1974 to 1986 in a preventive medicine study in Sweden, 5,722 men aged