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Congratulations to Academic Clinical Lecturer Dr Fadi Issa who has been awarded a four-year Wellcome Trust Clinical Research Career Development Fellowship in support of his project entitled ‘Investigation of hypoxia-sensing mechanisms in immune regulation’.
Association between deep cervical lymph node dissection and dementia incidence in patients with head and neck cancer: a systematic review
Journal article
Omar M. et al, (2026), European Journal of Plastic Surgery, 49
Resilience Engineering concepts, Safety-II language, FRAM practice, and co-creating communities: how Hollnagel reshaped patient safety
Journal article
Sujan M. et al, (2026), Safety Science, 200
Urine Recirculation During Normothermic Kidney Preservation Improves Energy Balance Involving the Urea and Citric Acid Cycles.
Journal article
Weissenbacher A. et al, (2026), Transplant Direct, 12
Clinical Equipoise and Unimproved Outcomes following Posttransplant Cutaneous Squamous Cell Carcinoma
Journal article
Crisp THJ. et al, (2026), Kidney International Reports, 11
Salvage surgery for residual and recurrent head and neck squamous cell carcinoma (RESCUE): An IReC multicentre consecutive cohort study.
Journal article
Williamson A. et al, (2026), Oral Oncol, 179
Intentional weight loss before endometrial cancer surgery to support postoperative recovery: the ENDO-CARE feasibility randomised controlled trial
Journal article
KOUTOUKIDIS DA. et al, (2026), The Lancet Obstetrics, Gynaecology, & Women’s Health
Pilot study on virtual reality teaching of the gastrointestinal tract vasculature
Conference paper
Smilevska RS. et al, (2026)
Temporal relationship between hematoma resolution and functional recovery after middle meningeal artery embolization for chronic subdural hematoma.
Journal article
DeMessie B. et al, (2026), J Neurosurg, 1 - 12
Protocol for a phase I single-centre dose escalation trial of autologous thymus derived regulatory T cells in paediatric heart transplant recipients to prevent cardiac allograft vasculopathy (ATT-Heart).
Journal article
Aiyengar A. et al, (2026), BMJ Open, 16
The Causal Role of Adiposity in Mental Illness: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.
Journal article
Gao M. et al, (2026), Obes Rev
Woven Endobridge device for ruptured vs. unruptured aneurysms: insights from the WorldWideWEB study.
Journal article
Dugar F. et al, (2026), Neuroradiology
Pain outcomes from past patients after total knee arthroplasty: regression tree analysis to generate insights for new patients
Conference paper
Revaz M. et al, (2026)
Accuracy of Diagnosis in Myeloproliferative Neoplasms With Splanchnic Vein Thrombosis (MPN-SVT).
Journal article
Sreedhar BR. et al, (2026), Am J Hematol
Elevated Tmax >4 Seconds Volume Predicts Worse Functional Outcome Following Endovascular Treatment in M2 Middle Cerebral Artery Occlusion.
Journal article
Kiani I. et al, (2026), AJNR Am J Neuroradiol
Refining the Multivariable Predictive‐Prognostic PREDICTR ‐ OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma
Journal article
Zhang LL. et al, (2026), The Laryngoscope
Conventional type-1 DC density is associated with checkpoint inhibitor response across multiple types of cancer.
Journal article
Lopez-Janeiro A. et al, (2026), J Clin Invest, 136
The PRAGMATIC pathway - PRostate cancer diAGnosis and MAnagement Triage In Clinical care.
Journal article
Sharma A. et al, (2026), BJU Int, 137, 849 - 857
Meet the researcher
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Fadi Issa
Professor of Transplantation, Associate Head & Surgical Sciences Theme Lead
Project summary
How does the immune system respond to changes in oxygen levels?
Our immune system has an astounding ability to respond to infections while remaining tolerant towards our own cells. This equilibrium is maintained when we are healthy. However, a breakdown can result in an immune imbalance and the inability to respond appropriately to infections and tumours, as well as the development of autoimmune diseases. The factors responsible for this balance are not yet fully understood, but may be related to how T cells respond to low levels of oxygen. In order to investigate this, Dr Issa will use genetically altered cells that behave as if they are in a low oxygen environment. Studying the way in which these cells perform will provide valuable insight into diseases of immune dysfunction and open up the possibilities for manipulating immune cells to produce better outcomes for patients with transplants, autoimmune diseases, and perhaps cancer.