John Radcliffe Hospital, Level 6, Headley Way, Headington, Oxford, OX3 9DU
Associate Professor of Plastic Surgery
- Wellcome Trust CRCD Fellow
- Consultant Plastic and Reconstructive Surgeon
- Lecturer in Physiology
I jointly lead the Transplantation Research Immunology Group (TRIG) together with Dr Joanna Hester. TRIG is a dynamic group of graduate students, postdoctoral researchers and junior clinical academics with an interest in immune regulation. Our work spans basic science discoveries to early phase clinical trials of novel therapeutics. My research interests are focused on manipulating the immune system with a view to improving outcomes after transplantation. I am particularly interested in the effects of hypoxia and the HIF system on immune responses as well as the mechanisms of rejection and regulation of skin transplants. Together with Dr Paul Harden and Professor Peter Friend, I am currently investigating regulatory T cell (Treg) therapy in renal transplantation in the MRC DPFS-funded Phase IIb TWO Study.
I Chair the Transplantation Science Committee and Co-Chair the Young Members Committee of the TTS, and I am a member of the ESOT VCA Committee. I am an Associate Editor of the journal Transplantation. I am keen to promote basic and translational research to junior clinicians. If you are interested in joining our group in the future please get in touch with me or Joanna Hester (firstname.lastname@example.org). Open positions are always advertised in the University's Gazette and online.
Chimeric antigen receptor-modified human regulatory T cells that constitutively express interleukin-10 maintain their phenotype and are potently suppressive
ISSA F., (2021), European Journal of Immunology
Scar assessment tools: how do they compare?
ISSA F., (2021), Frontiers in Surgery
Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo
Adigbli G. et al, (2021), Frontiers in Immunology, 12
Obesity Induces Gut Microbiota Alterations and Augments Acute Graft-versus-host Disease After Allogeneic Stem Cell Transplantation
McCallion O. and Issa F., (2021), TRANSPLANTATION, 105, 271 - 272
Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?
Stark HL. et al, (2021), Front Immunol, 12