Associate Professor of Plastic Surgery
- Wellcome Trust CRCD Fellow
- Consultant Plastic and Reconstructive Surgeon
- Lecturer in Physiology
I jointly lead the Transplantation Research Immunology Group (TRIG) together with Dr Joanna Hester. TRIG is a dynamic group of graduate students, postdoctoral researchers and junior clinical academics with an interest in immune regulation. Our work spans basic science discoveries to early phase clinical trials of novel therapeutics. My research interests are focused on manipulating the immune system with a view to improving outcomes after transplantation. I am particularly interested in the effects of hypoxia and the HIF system on immune responses as well as the mechanisms of rejection and regulation of skin transplants. Together with Dr Paul Harden and Professor Peter Friend, I am currently investigating regulatory T cell (Treg) therapy in renal transplantation in the MRC DPFS-funded Phase IIb TWO Study.
I Chair the Transplantation Science Committee and Co-Chair the Young Members Committee of the TTS, and I am a member of the ESOT VCA Committee. I am an Associate Editor of the journal Transplantation. I am keen to promote basic and translational research to junior clinicians. If you are interested in joining our group in the future please get in touch with me or Joanna Hester (email@example.com). Open positions are always advertised in the University's Gazette and online.
Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use
Alzhrani A. et al, (2020), Cellular Immunology
Letter re: Nepogodiev D, Glasbey JC, Li E et al. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
RODRIGUES J. et al, (2020), The Lancet
IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation
ISSA F. et al, (2020), American Journal of Transplantation
Regulatory B cells in transplantation: Roadmaps to clinic.
Beckett J. et al, (2020), Transpl Int
CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells.
Arroyo Hornero R. et al, (2020), Commun Biol, 3