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The Translational Research Immunology Group (TRIG) is interested in translational aspects of immunological research in transplantation, cancer and autoimmunity. Our group is a dynamic, multi-disciplinary international team of around 20 scientists, clinician scientists and students.

Immunofluoresent microscopy of lung tissue from a COVID-19 patient and a heatmap exploring the transcriptional signatures across the lung.

The focus of our research has been the exploration of the mechanisms and features of immunological tolerance with the goal of translating our research from the lab into the clinic. 

Our principal aims are:

-          Answering important basic science questions in immune regulation

-          Linking these with clinical observations

-          Training the next generation of scientists

-          Developing cellular therapies and assessing these in clinical trials

 

Our work spans from the investigation of basic biology of regulatory T cells and other regulatory immune cells, via translational research in pre-clinical and clinical settings to the clinical trials investigating our translational innovations.

 

Our technical expertise includes:

-          Spatial profiling (Nanosting GeoMx)

-          Flow cytometry and cell sorting

-          Immune monitoring in clinical trials

-          Multiplex gene expression analysis (Nanostring nCounter)

-          Complexed primary immune cells expansions

-          Pre-clinical in vivo models

 

Our work is supported with substantial funding from the Wellcome Trust, the Medical Research Council, and the European Union. We also receive funding from KRUK (Kidney Research UK), RESTORE (Burn and Wound Research), RCS (Royal College of Surgeons), Oxford-BMS Fellowship Programme, OHSRC (Oxfordshire Health Research Services Committee), the Academy of Medical Sciences, and the University of Oxford Medical Research Fund - we are grateful to all our funders for allowing us to continue with our research.

Our team

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