Transplantation Research Immunology Group (TRIG)
- +44 (0) 1865 222508
Started in 1982
Celebrating over 30 years of science
Over 330 publications to date
Multi-disciplinary international team
Our research focuses on understanding and controlling the cellular and molecular events that lead to transplant rejection, with the aim of improving long-term outcomes for transplant recipients.
Our group is a dynamic, multi-disciplinary international team of around 18 scientists and clinician scientists. We are dedicated to translating our research from the lab into the clinic by finding new ways to diagnose and treat patients, with the aim of optimising patient care, and prolonging the life of a donated organ.
With this in mind, we are investigating how to :
- increase the selectivity of immunosuppression such that only the destructive responses the immune system makes against the transplant are suppressed
- predict the when rejection is going to happen more reliably to enable anti-rejection treatment to be started before the transplant has actually been damaged by the immune response
Advances in each of these areas would allow immunosuppressive drug therapy to be tailored to the specific needs of the individual transplant recipient. In other words, the development of personalised or precision medicine for each individual transplant patient.
Our work is supported with substantial funding from Kidney Research UK, the Medical Research Council, and the European Union. We also receive funding from RESTORE (Burn and Wound Research), OHSRC (Oxfordshire Health Research Services Committee), the Academy of Medical Sciences, and the University of Oxford Medical Research Fund - we are grateful to all our funders for allowing us to continue with our research.
Congratulations to ...........
Dr Fadi Issa, senior Post-doc, who won the prize for the best oral presentation at the NDS awayday on 19th January 2017.
Rebeca Arroyo, 2nd year DPhil student, who has won the Transplantation Society Mentor-Mentee Award for her talk entitled: "CD45RA identifies TSDR demethylated regulatory T cells with stable phenotype and suppressive cytokine profile" at the 26th International Congress of Transplantation Society (August 2016).
Rebeca also won a travel grant from BIO-DrIM to attend the FOCIS European Advanced Course in Basic and Clinical Immunology (October 2016).
She has also presented a couple of posters recently - "The role of CD27 in stability and suppressive function of human regulatory T cells" at the BSI/NVI Congress. (December 2016)
- "Identification of functionally stable and immunusuppression-resistant human regulatory T cells through CD45RA". FOCIS European Advanced Course n Basic and Clinical Immunology (October 2016).
Andrew Whatcott, Dr Matt Bottomley and Dr Sushma Shankar who all successfully defended their thesis in 2016.
The TWO Study
A multi-disciplinary team led by TRIG has been awarded a grant of c£2.5m to undertake a pioneering clinical trial of cellular therapy in renal transplantation. The TWO Study aims to assess the feasibility of reducing immunosuppression in renal transplant recipients with the use of regulatory T cells (Treg). The trial will be led by Dr Fadi Issa (PI), Dr Paul Harden (Co-PI & Clinical Lead), Professor Peter Friend (Chief Investigator) and Dr Joanna Hester (Immune Biology Lead), together with Professor Giovanna Lombardi of King’s College London, senior researchers from TRIG, the Oxford Transplant Centre, the University’s Surgical Trials Intervention Unit, Oxford University Innovation, and the BRC GMP facility at Guy’s and St Thomas’ NHS Foundation Trust.
The trial aims to recruit 68 patients over a three-year period, with those receiving the cellular therapy donating a unit of blood for isolation of Tregs. Isolated Treg will then be expanded in a purpose-built GMP facility at Guy's Hospital in London. The function of kidney transplants will be assessed and the amount of drug-based immunosuppression reduced accordingly. Patients will be closely monitored and potential early markers of improved immune function will be determined using advanced assessment techniques.
For more information about the project please contact Monica Dolton, Project Manager email@example.com
Dr Andrew Bushell - Travel Award Fund Launched in Memory of Andrew's Contribution to Research
As some of you already know, Andrew Bushell passed away in December 2016 after a period of illness. He made so many contributions to the field of transplantation and, of course, to the Wood Lab/TRIG over the 33 years that he was in the group and is fondly remembered by his friends and colleagues.
We have decided that the very best way to celebrate Andrew’s career and all of his contributions to the success of the Wood Lab/TRIG is by setting up a travel fund to help provide travel bursaries for graduate students and early career researchers to attend meetings. It is getting harder and harder to find funds to send researchers to meetings so that they can gain the invaluable experience of presenting their work to an international audience. Andrew was passionate about educating and training young scientists. He put his heart into making sure that all of his graduate students did their very best work and Andrew was very proud of the achievements of all of the students and fellows that have been members of the Wood Lab/TRIG over the years.
The University of Oxford Development Office have kindly agreed to support this initiative and host a webpage where donations can be made. Our initial target would be to fund at least two Andrew Bushell Travel Bursaries per year of the order of £700 - £1000 each per year for 5 years. We therefore have an initial target of £10,000.
If you would like to remember Andrew in this way please follow the link below.
If you would like any further information about how the fund will work, please contact Monica Dolton: firstname.lastname@example.org