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Imaging immune cells after transplanation © © TRIG image
Imaging immune cells after transplanation

Our group is a dynamic, multi-disciplinary international team of around 12 scientists,clinician scientists and students. We are dedicated to translating our research from the lab into the clinic by finding new ways to diagnose and treat patients, with the aim of optimising patient care, and prolonging the life of a donated organ.

With this in mind, we are investigating how :

  1. to increase the selectivity of immunosuppression such that only the destructive responses the immune system makes against the transplant are suppressed
  2. to predict when the rejection is going to happen more reliably to enable anti-rejection treatment to be started before the transplant has actually been damaged by the immune response
  3. we may be able to reduce immunosuppression in renal transplant recipients with the use of regulatory T cells (Treg) in a pioneering clinical trial of cellular therapy in renal transplantation (The TWO Study)

Advances in each of these areas would allow immunosuppressive drug therapy to be tailored to the specific needs of the individual transplant recipient. In other words, the development of personalised or precision medicine for each individual transplant patient.

Our work is supported with substantial funding from  the Wellcome Trust, the Medical Research Council, and the European Union. We also receive funding from RESTORE (Burn and Wound Research), OHSRC (Oxfordshire Health Research Services Committee), the Academy of Medical Sciences, and the University of Oxford Medical Research Fund - we are grateful to all our funders for allowing us to continue with our research.

Our team

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